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目的 提高临床对卵巢癌卡铂腹腔热灌注化疗(HIPEC)过敏反应的警惕性，建立标准化急救流程与护理方案。方法 详细报告1例卵巢癌患者在卡铂腹腔热灌注化疗中发生过敏性休克的临床资料、急救与护理过程。结果 经抢救后，患者血压、心率、呼吸、SpO2、意识状态逐渐改善，且抢救2h后，患者以上生命体征完全恢复正常。经抢救后，患者乳酸、pH、PaO2、BE水平均改善。结论 通过精细化风险评估、标准化急救流程及系统化护理干预，可有效提高抢救成功率，改善患者预后。
Abstract：Objective To enhance clinical vigilance regarding anaphylactic reactions induced by hyperthermic intraperitoneal chemotherapy(HIPEC) with carboplatin in ovarian cancer patients, and to establish standardized emergency protocols and nursing strategies. Methods Provides a detailed report of the clinical data, emergency management, and nursing process of a case of anaphylactic shock occurring during HIPEC with carboplatin in an ovarian cancer patient. Results After resuscitation, the patient's blood pressure, heart rate, respiratory rate, SpO2, and consciousness gradually improved. All vital signs returned to normal within 2 hours post-resuscitation. Additionally, lactate levels, pH, PaO2, and base excess(BE) levels showed significant improvement. Conclusion Refined risk assessment, standardized emergency procedures, and systematic nursing interventions can effectively increase the success rate of resuscitation and improve patient outcomes.
[1] Siegel RL, Kratzer TB, Giaquinto AN, et al. Cancer statistics, 2025[J]. CA Cancer J Clin, 2025, 75(1):10-45.
[2] Li J, Zhao L, Zheng F, et al. PARP Inhibitors Rechallenge in Patients With Recurrent Ovarian Cancer:A Multicentre RealWorld Study in China[J]. BJOG, 2025, 132 Suppl 4:45-51.
[3] Xie L, Lin S, Liu Y, et al. The Forefront of Maintenance Therapy for Newly Diagnosed Advanced Ovarian Cancer in China:A Review of Updated Evidence With PARP Inhibitors[J].BJOG, 2025, 132 Suppl 4:5-12.
[4] Simmons D, White J, Walker V, et al. Validation of an Administrative Claims-based Line of Therapy Algorithm for Women with Ovarian Cancer Using Medical Chart Review[J]. Adv Ther, 2025, 42(6):2754-2766.
[5] Harter P, Bogner G, Chiva L, et al. Statement of the AGO Kommission Ovar, AGO Study Group, NOGGO, AGO Austria,Swiss AGO, BGOG, CEEGOG, GEICO, and SFOG regarding the use of hyperthermic intraperitoneal chemotherapy(HIPEC)in epithelial ovarian cancer[J]. Bull Cancer, 2024, 111(3):277-284.
[6] Ghirardi V, Trozzi R, Scambia G, et al. Current and future trials about HIPEC in ovarian cancer[J]. Bull Cancer, 2024,111(3):254-260.
[7]卢淮武,吴斌,许妙纯,等.《2022 NCCN卵巢癌包括输卵管癌及原发性腹膜癌临床实践指南（第1版）》解读[J].中国实用妇科与产科杂志, 2022, 38(3):310-318.
[8]詹慧旦,马莹,郑锦萍. 1例卡铂药物致过敏性休克患者的急救与护理[J].当代护士(上旬刊), 2021, 28(2):177-178.
[9]邱晨,张师前.妇科肿瘤卡铂化疗所致过敏反应的中国专家共识（2022年版）[J].肿瘤药学, 2022, 12(4):413-421+549.
[10] Chen S, Lin Y, Gao S, et al. Anesthesia management of CRS and HIPEC in advanced ovarian cancer with ultra-high intra-abdominal pressure:a case report[J]. Front Oncol, 2024,14:1449171.
[11]王希洪. 1例卵巢癌卡铂腹腔热灌注化疗患者发生过敏性休克的急救与护理[J].中西医结合护理(中英文), 2020,6(6):199-201.
[12]孔北华,李小平,姜洁,等.妇科恶性肿瘤紫杉类药物临床应用指南(2025版)[J].现代妇产科进展, 2025, 34(5):321-330.
[13]黄惠涛,张瑞.卡铂过敏反应及皮试临床应用价值研究进展[J].中国医院药学杂志, 2023, 43(01):112-116,120.
[14]宋少练,李园,卢澄钰,等.注射用卡铂致严重变态反应1例[J].医药导报, 2025, 44(2):311-313.
基本信息:
DOI：10.13919/j.issn.2095-6274.ZHJY202507006
中图分类号:R737.31
引用信息:
[1]李颖超,范俊娟,郑倩倩,等.卵巢癌卡铂腹腔热灌注化疗致过敏性休克一例并文献复习[J].中华灾害救援医学,2025,12(07):775-778.DOI:10.13919/j.issn.2095-6274.ZHJY202507006.
基金信息:
山西省卫生健康委办公室关于下达2024年度卫生健康科研课题计划的通知（2024159）
2025-07-28
2025-07-28